Evaluation of the pharmaceutical quality of some quinine preparations sold in Nigeria.
نویسندگان
چکیده
OBJECTIVE The purpose of this study was to determine the pharmaceutical quality of quinine preparations sold in Nigerian markets. MATERIALS AND METHODS The organoleptic and physicochemical properties of quinine tablets, as well as oral liquids and parenteral quinine preparations, were assessed according to British Pharmacopoeia (BP) and unofficial standards as recommended by the manufacturers. RESULTS Of the 6 brands of tablets assessed, 4 passed the uniformity of content test and 5 the disintegration test, but only 2 the dissolution test. The pH of 2 of the 6 brands of oral liquid preparations met BP standards, while only 1 oral liquid met the BP standard for percentage content. The assay further demonstrated that 4 brands of the parenteral preparations met BP standards for quinine content. All the parenteral preparations were found to be sterile. CONCLUSION Quinine preparations sold in Nigeria varied considerably in their pharmaceutical quality. A strict check of the quality of brands of quinine by regulatory agencies and distributors before they are sold to the public is therefore recommended.
منابع مشابه
Evaluation of Levels of Potassium Bromate and Some Heavy Metals in Bread and Wheat Flour Sold in Aba Metropolis
متن کامل
Concentrations of Phthalates and Metals in Commercially Packaged Sachet and Plastic Bottled Water Sold in Lagos, Nigeria
Background: In many developing countries, numerous brands of bottled water and the relatively cheaper counterpart, sachet water, can be found in all cities, towns, and even villages. This study assessed the concentrations of some phthalates and metals in bottled and sachet water sold in Lagos, Nigeria. Methods: Fifteen pieces of plastic bottled water and 15 pieces of sachet water were randomly...
متن کاملLoad and Antibiotic Susceptibility Pattern of Microorganisms in Muscle Foods Sold in Akure, Southwest Nigeria
Background: Muscle foods, notably red meat, poultry meat, and fish are the first choice of animal source food with adequate protein for human. The present study was undertaken to analyze the load and antibiotic susceptibility pattern of microorganisms in muscle foods sold in Akure, Southwest Nigeria. Methods: Hundred muscle food samples, including meat and fish were collected from different lo...
متن کاملAssessing the Household Food Insecurity Status and Coping Strategies in Abeokuta, Ogun State, Nigeria
Background: High prevalence of food insecurity experienced by many households in developing countries predisposes them to adopting coping strategies (CSs), some of which may put them at risk of malnutrition. This study assessed the household food insecurity status and CSs in Abeokuta. Methods: A cross-sectional study design was adopted. A total of 250 households were randomly selected in all c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre
دوره 18 3 شماره
صفحات -
تاریخ انتشار 2009